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KMID : 1007519980070010046
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Food Science and Biotechnology
1998 Volume.7 No. 1 p.46 ~ p.50
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Immunostimulative Effect of Commercial Bifidobacteria used in Yogurt Culture Starters
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Lee Jong-Hwa
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Abstract
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Three commercial bifidobacteria were isolated from yogurt starters and the immunostimulative activities were investigated. All the commercial bifidobacteria showed dose-dependent mitogenic activity in the range of 10^6∼10^8 bacteria/mL, and significantly enhanced the antibody production of lymph node cells in vitro. The Iysosomal enzyme activity of murine macrophages was increased by the intraperitoneal injection of those bifidobacteria. Furthermore, commercial bifidobacteria enhanced glucose consumption, nitrite production and the production of cytokines such as IL-6 and TNF-α in the culture of peptoneinduced peritoneal macrophages. Our observations suggest that bifidobacteria, especially commercial bifidobacteria, have murine lymphocytes and macrophage stimulation qualities in vivo as well as in vitro. It is thought that bifidobacteria are useful for a non-toxic immunopotentiator to maintain the host defense system and develop a physiologically functional dairy food.
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